ABCC2

Across TCGA patient cohorts, ABCC2 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCC2-associated genes across cancer lineages are ATM, Shc_pY317, and STAT3_pY705. Each is linked with ABCC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ABCC2-to-partner and partner-to-ABCC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ABCC2-low versus ABCC2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCC2→partner) and Y-score (partner→ABCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.554	-1.991	<.001	.031	3	4
UCEC	Shc_pY317 →	-0.108	-1.169	.005	.015	3	3
COAD	STAT3_pY705 →	-0.269	-3.157	.010	.018	3	3
UCEC	ASNS →	+0.205	+1.000	.026	.048	3	3
SKCM	Caspase-8 →	-0.158	-1.700	.009	.043	3	3
SKCM	Caveolin-1 →	-0.745	-1.874	.004	.049	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

ATM by ABCC2 expression — COAD

Explore this box plot interactively →