ABCC12

Across TCGA patient cohorts, ABCC12 mutation is significantly associated with the total protein of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCC12-associated genes across cancer lineages are Cyclin-E2, ERK2, and TFRC. Each is linked with ABCC12 in more than 4 cancer types. Because this analysis shows association rather than direction, both ABCC12-to-partner and partner-to-ABCC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by ABCC12-low versus ABCC12-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCC12→partner) and Y-score (partner→ABCC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-E2 →	+0.187	+2.025	.035	.016	3	5
UCEC	ERK2 →	+0.125	+1.247	.025	.041	3	4
COAD	TFRC →	+0.412	+2.459	.042	.018	3	4
UCEC	MEK1 →	+0.386	+2.584	<.001	<.001	3	3
UCEC	p27_pT198 →	+0.069	+2.700	.026	.005	3	3
UCEC	PCNA →	+0.204	+1.906	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

Cyclin-E2 by ABCC12 expression — COAD

Explore this box plot interactively →