AASS

Across TCGA patient cohorts, AASS mutation is significantly associated with the RNA expression of many other genes, with 6,365 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AASS-associated genes across cancer lineages are CHCHD4, PBK, and SEH1L. Each is linked with AASS in more than 3 cancer types. Because this analysis shows association rather than direction, both AASS-to-partner and partner-to-AASS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHCHD4 grouped by AASS-low versus AASS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AASS→partner) and Y-score (partner→AASS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHCHD4 →	+0.409	+1.606	<.001	<.001	3	4
UCEC	PBK →	+1.191	+2.974	<.001	<.001	3	4
UCEC	SEH1L →	+0.483	+1.638	<.001	<.001	3	4
UCEC	LEPROTL1 →	+0.367	+3.202	<.001	<.001	3	4
UCEC	GOT1 →	+0.461	+2.727	<.001	<.001	3	4
BLCA	SUN5 →	+0.072	+2.529	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,365 associations by consensus.

CHCHD4 by AASS expression — UCEC

Explore this box plot interactively →