AASS

Across TCGA pan-cancer cohorts, AASS RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated AASS data layer compared with 8 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher AASS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated AASS expression acts as an unfavorable survival marker, although some lineages such as BRCA and LIHC show a favorable association.

STAD, UVM, and LGG are the cancer types where AASS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Quartile	All	0.458	0.645	.003	83	view →
UVM	OS	Tertile	III,IV	0.340	0.938	.001	62	view →
LGG	DFS	Median	All	0.778	0.889	<.001	48	view →
BRCA	OS	Quartile	III,IV	0.907	0.746	.006	45	view →
LIHC	OS	Median	All	0.755	0.621	.002	44	view →
SCLC	DFS	Tertile	III,IV	0.751	0.301	.001	35	view →
KIRC	DFS	Median	All	0.866	0.722	.001	31	view →
ESCA	OS	Tertile	All	0.752	0.558	.016	27	view →
DLBC	DFS	Median	All	0.447	1.000	.024	18	view →
LUAD	OS	Quartile	III,IV	0.604	0.361	.009	16	view →
GBM	OS	Median	All	0.480	0.348	.010	15	view →
MESO	DFS	Median	II,III,IV	0.262	0.638	.003	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

AASS–STAD (DFS)

Open the STAD breakdown →