AASS

Across TCGA pan-cancer cohorts, AASS RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of AASS’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where AASS RNA is repressed in tumor relative to normal tissue. In most cancer types AASS is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and UCEC are the cancer types where AASS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AASS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.040	<.001	12	view →
KICH	Male	IV	−2.516	<.001	11	view →
UCEC	All	All	−1.729	<.001	8	view →
THCA	Male	II,III,IV	−1.318	<.001	8	view →
BRCA	All	III,IV	−1.452	<.001	6	view →
KIRP	Male	All	−0.760	.002	5	view →
LUAD	All	II,III,IV	−0.553	.016	5	view →
LIHC	All	II,III,IV	−1.130	.001	4	view →
BLCA	All	IV	−1.078	.009	4	view →
CHOL	All	All	−2.253	<.001	3	view →
LUSC	Male	All	−0.661	.001	3	view →
ESCA	All	All	−0.836	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

AASS–KIRC

Open the KIRC breakdown →