AASS

Across TCGA patient cohorts, AASS mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AASS-associated genes across cancer lineages are eEF2, eIF4G, and A-Raf_pS299. Each is linked with AASS in more than 1 cancer types. Because this analysis shows association rather than direction, both AASS-to-partner and partner-to-AASS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by AASS-low versus AASS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AASS→partner) and Y-score (partner→AASS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.301	+2.222	.004	.009	3	2
UCEC	eIF4G →	+0.213	+1.184	.021	.022	3	2
UCEC	A-Raf_pS299 →	-0.111	-1.514	.001	.014	3	2
UCEC	FoxM1 →	+0.163	+1.378	.035	.008	3	2
UCEC	GAPDH →	+0.408	+2.169	.010	.002	3	2
UCEC	Ku80 →	+0.255	+1.820	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

eEF2 by AASS expression — UCEC

Explore this box plot interactively →