AASS

Across TCGA cell cohorts, AASS mutation is significantly associated with the RNA expression of many other genes, with 538 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AASS-associated genes across cancer lineages are ENPP6, IL5RA, and FOXR1. Each is linked with AASS in more than 1 cancer types. Because this analysis shows association rather than direction, both AASS-to-partner and partner-to-AASS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENPP6 grouped by AASS-low versus AASS-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AASS→partner) and Y-score (partner→AASS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ENPP6 →	+0.019	+1.945	.007	<.001	3	2
LARGE_INTESTINE	IL5RA →	+0.036	+1.570	.006	.008	3	2
LUNG_SCLC	FOXR1 →	+0.207	+3.736	<.001	.007	3	1
LUNG_SCLC	KRTAP9-3 →	+0.033	+4.058	<.001	.007	3	1
LUNG_SCLC	MTRNR2L6 →	+0.037	+3.817	<.001	.004	3	1
URINARY_TRACT	KRTAP4-12 →	+0.233	+4.217	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 538 associations by consensus.

ENPP6 by AASS expression — LARGE_INTESTINE

Explore this box plot interactively →