AARS2

Across TCGA patient cohorts, AARS2 protein abundance is significantly associated with the RNA expression of many other genes, with 7,524 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AARS2-associated genes across cancer lineages are POLR1C, BYSL, and DNPH1. Each is linked with AARS2 in more than 5 cancer types. Because this analysis shows association rather than direction, both AARS2-to-partner and partner-to-AARS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AARS2 versus POLR1C in HNSC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AARS2→partner) and Y-score (partner→AARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	POLR1C →	+0.802	+0.292	<.001	<.001	3	6
OV	BYSL →	+0.760	+0.264	<.001	.002	3	5
OV	DNPH1 →	+0.800	+0.257	<.001	<.001	3	5
HNSC	NFYA →	+0.746	+0.267	.002	<.001	3	4
LSCC	XPO5 →	+0.595	+0.252	<.001	<.001	3	4
LSCC	ABCC10 →	+0.731	+0.381	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,524 associations by consensus.

AARS2 vs POLR1C — HNSC

Explore this scatter interactively →