AARS2

Across TCGA pan-cancer cohorts, AARS2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated AARS2 data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher AARS2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated AARS2 expression acts as an unfavorable survival marker, although some lineages such as SCLC and UCS show a favorable association.

COAD, ACC, and KICH are the cancer types where AARS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	All	0.696	0.857	.001	82	view →
ACC	DFS	Tertile	All	0.263	0.778	<.001	73	view →
KICH	OS	Quartile	All	0.607	1.000	.002	47	view →
MESO	DFS	Quartile	III,IV	0.122	0.671	.010	42	view →
SCLC	OS	Quartile	III,IV	0.547	0.189	.011	38	view →
LIHC	DFS	Median	All	0.466	0.617	<.001	32	view →
UCEC	DFS	Median	All	0.796	0.878	.002	30	view →
SARC	OS	Tertile	All	0.639	0.829	.001	29	view →
UCS	OS	Median	II,III,IV	0.595	0.247	.008	22	view →
KIRC	DFS	Tertile	IV	0.696	0.298	.005	18	view →
PAAD	DFS	Median	II,III,IV	0.371	0.218	.020	16	view →
LUSC	DFS	Quartile	III,IV	0.531	0.819	.014	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

AARS2–COAD (DFS)

Open the COAD breakdown →