AARS2

Across TCGA cell cohorts, AARS2 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AARS2-associated genes across cancer lineages are CNNM1, GALR3, and HRH4. Each is linked with AARS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AARS2-to-partner and partner-to-AARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNNM1 grouped by AARS2-low versus AARS2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AARS2→partner) and Y-score (partner→AARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CNNM1 →	+0.824	+3.040	.001	.002	3	1
LARGE_INTESTINE	GALR3 →	+0.093	+3.646	.001	.002	3	1
LARGE_INTESTINE	HRH4 →	+0.053	+3.215	.004	.009	3	1
LARGE_INTESTINE	KRT85 →	+0.299	+2.560	.001	.009	3	1
LARGE_INTESTINE	CX3CR1 →	+0.161	+3.215	<.001	.009	3	1
LARGE_INTESTINE	TRDN →	+0.032	+3.054	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

CNNM1 by AARS2 expression — LARGE_INTESTINE

Explore this box plot interactively →