AAK1

Across TCGA patient cohorts, AAK1 mutation is significantly associated with the RNA expression of many other genes, with 4,942 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AAK1-associated genes across cancer lineages are RNU6-264P, RNLS, and GPR143. Each is linked with AAK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AAK1-to-partner and partner-to-AAK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-264P grouped by AAK1-low versus AAK1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AAK1→partner) and Y-score (partner→AAK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-264P →	+0.140	+3.362	.004	.006	3	3
UCEC	RNLS →	-0.576	-1.868	<.001	<.001	3	3
UCEC	GPR143 →	-0.640	-2.705	<.001	<.001	3	3
LIHC	H3P8 →	+0.161	+4.607	<.001	.004	3	2
HNSC	OR4K5 →	+0.090	+5.912	<.001	.002	3	2
BLCA	RNU6-1128P →	+0.557	+4.167	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,942 associations by consensus.

RNU6-264P by AAK1 expression — SKCM

Explore this box plot interactively →