AAK1

Across TCGA pan-cancer cohorts, AAK1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of AAK1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AAK1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AAK1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where AAK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AAK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.164	<.001	12	view →
THCA	Male	III,IV	−1.947	<.001	11	view →
LIHC	Female	II,III,IV	+1.172	<.001	9	view →
KICH	All	All	−0.719	<.001	6	view →
KIRC	Male	III,IV	−0.552	<.001	6	view →
BLCA	All	IV	+0.604	.009	5	view →
COAD	Female	All	−0.547	.001	4	view →
LUSC	Male	All	+0.418	<.001	4	view →
CHOL	All	All	+2.053	<.001	3	view →
UCEC	All	All	−0.589	.002	2	view →
PRAD	All	All	+0.517	<.001	2	view →
KIRP	Female	All	+0.540	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

AAK1–HNSC

Open the HNSC breakdown →