Q-omics provides the consensus-scored A2MP1 profile across patient tissues and cancer cell-line models. A2MP1 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, A2MP1 is differentially expressed in 11, with the highest sampling consensus in LUSC. Additionally, A2MP1 RNA expression shows 17,246 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight HNSC, LUSC, and LSCC as cancer lineages where A2MP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for A2MP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes A2MP1 survival associations across molecular data types. A2MP1 RNA expression shows survival associations in the most cancer types (24). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible A2MP1 RNA expression–survival associations across cancer types. High A2MP1 expression shows unfavorable associations in DLBC and UVM, but favorable associations in HNSC, SKCM, LUAD and ESCA. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for A2MP1 RNA expression.
This table summarizes A2MP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for A2MP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. A2MP1 shows lower tumor expression in LUSC, KICH, BRCA, COAD and LUAD and higher tumor expression in KIRC. The LUSC box plot shows higher A2MP1 RNA expression in normal versus tumor tissue (log2 FC = −0.521, t-test p < 0.001).
This table shows molecular features associated with A2MP1 in patient tissues and cancer cell lines. In patient samples, A2MP1 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set.
