A2MP1

Across TCGA pan-cancer cohorts, A2MP1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated A2MP1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher A2MP1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated A2MP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and DLBC are the cancer types where A2MP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.446	0.261	<.001	131	view →
SKCM	OS	Median	All	0.851	0.709	<.001	100	view →
DLBC	DFS	Median	III,IV	0.366	1.000	<.001	61	view →
LUAD	DFS	Median	All	0.735	0.606	.001	50	view →
ESCA	DFS	Median	II,III,IV	0.602	0.388	.002	49	view →
PAAD	DFS	Quartile	All	0.705	0.349	.005	31	view →
KIRC	DFS	Median	II,III,IV	0.424	0.606	.003	31	view →
UVM	OS	Median	III,IV	0.304	1.000	.008	31	view →
LGG	OS	Median	All	0.865	0.759	.001	25	view →
LAML	DFS	Tertile	All	0.437	0.651	.010	24	view →
BLCA	DFS	Median	All	0.703	0.496	.007	21	view →
READ	DFS	Quartile	III,IV	0.234	0.688	.014	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

A2MP1–HNSC (DFS)

Open the HNSC breakdown →