A1CF

Across TCGA patient cohorts, A1CF protein abundance is significantly associated with the RNA expression of many other genes, with 9,664 significant associations in total. COAD shows the largest number of these associations.

The most reproducible A1CF-associated genes across cancer lineages are KIF12, ARL4C, and ABCC6P2. Each is linked with A1CF in more than 3 cancer types. Because this analysis shows association rather than direction, both A1CF-to-partner and partner-to-A1CF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, A1CF versus KIF12 in LUAD, with a Pearson correlation of 0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (A1CF→partner) and Y-score (partner→A1CF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KIF12 →	+1.274	+1.302	.009	.005	3	4
COAD	ARL4C →	-1.110	-0.753	<.001	<.001	3	4
CCRCC	ABCC6P2 →	+1.371	+0.811	<.001	<.001	3	4
COAD	SGK2 →	+1.032	+0.565	<.001	<.001	3	3
LUAD	PIM2 →	-1.198	-2.108	.001	.009	3	3
LUAD	GIPC2 →	+1.152	+1.500	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,664 associations by consensus.

A1CF vs KIF12 — LUAD

Explore this scatter interactively →