A1CF

Across TCGA pan-cancer cohorts, A1CF RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated A1CF data layer compared with 8 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher A1CF RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated A1CF expression acts as an unfavorable survival marker, although some lineages such as KIRC and PAAD show a favorable association.

KIRC, LUAD, and THCA are the cancer types where A1CF RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.729	0.517	<.001	189	view →
LUAD	DFS	Quartile	All	0.489	0.730	<.001	123	view →
THCA	DFS	Tertile	II,III,IV	0.595	0.812	<.001	82	view →
HNSC	DFS	Tertile	All	0.250	0.409	<.001	55	view →
UVM	DFS	Median	III,IV	0.303	0.677	.001	48	view →
UCEC	DFS	Tertile	All	0.793	0.884	.008	32	view →
PAAD	DFS	Median	All	0.367	0.199	.002	22	view →
MESO	OS	Median	III,IV	0.036	0.563	<.001	21	view →
ESCA	OS	Quartile	II,III,IV	0.381	1.000	.015	18	view →
SCLC	OS	Median	All	0.810	0.625	.010	15	view →
BRCA	OS	Tertile	All	0.906	0.945	.007	14	view →
ACC	OS	Median	II,III,IV	0.355	0.787	.007	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

A1CF–KIRC (DFS)

Open the KIRC breakdown →