Mirin

Across CCLE and GDSC cell-line panels, response to Mirin is significantly associated with the shRNA dependency of multiple gene dependencies, with BLOOD_Myeloma cell lines showing a particularly strong set of associations.

The most reproducible Mirin response-associated gene dependencies across cancer lineages are SOD2, DOK3, and AURKAP1, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Mirin response versus SOD2 shRNA dependency in BLOOD_Myeloma (Pearson r = -0.65).

Shrna dependency biomarkers of Mirin response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SOD2 →	-0.239	-0.254	.020	.040	2	8
URINARY_TRACT	DOK3 →	+0.337	+1.086	.015	.041	2	8
LUNG_SCLC	AURKAP1 →	-0.222	-0.427	.001	.036	3	7
LUNG_SCLC	RAD23A →	-0.201	-0.472	.047	.031	2	8
OVARY	B4GALT3 →	+0.171	+0.874	.010	.004	3	7
LUNG_SCLC	UFC1 →	-0.244	-0.539	.008	.011	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Mirin response vs SOD2 — BLOOD_Myeloma

Explore this scatter interactively →