Regulation of store-operated calcium entry

Across TCGA patient cohorts, RNA activity of the Regulation of store-operated calcium entry pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HOMER2, CRIP2_S195, and ANAPC1_S688, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of store-operated calcium entry activity versus HOMER2 in PDAC (Pearson r = 0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HOMER2 →	+0.514	+0.050	<.001	<.001	3	5
CCRCC	CRIP2_S195 →	+0.567	+0.090	.001	<.001	3	4
OV	ANAPC1_S688 →	-0.808	-0.045	.002	.002	3	4
LSCC	ATP9A →	+0.369	+0.042	.001	.008	3	4
UCEC	SHANK2_S452 →	+0.526	+0.059	<.001	.003	3	4
LSCC	WRN_S1133 →	-0.520	-0.047	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001256 vs HOMER2 — PDAC

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