Regulation of phosphatidylcholine biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of phosphatidylcholine biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF3A, RAB11FIP5, and CAMK1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phosphatidylcholine biosynthetic process activity versus EIF3A in GBM (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EIF3A →	-0.125	-0.081	.004	.002	3	7
LSCC	RAB11FIP5 →	+0.273	+0.085	<.001	.001	3	7
LUAD	CAMK1 →	+0.405	+0.148	<.001	<.001	3	6
GBM	RPL21 →	-0.237	-0.091	<.001	<.001	3	6
LUAD	RPS3 →	-0.149	-0.080	<.001	<.001	3	6
GBM	RPS3A →	-0.200	-0.082	.003	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001245 vs EIF3A — GBM

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