Regulation of phosphatidylcholine biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of phosphatidylcholine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2BC5, KLHL30, and TMEM139, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phosphatidylcholine biosynthetic process activity versus H2BC5 in OESOPHAGUS (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	H2BC5 →	-2.193	-0.305	.002	.008	3	2
OESOPHAGUS	KLHL30 →	+0.481	+0.335	.006	.002	3	2
OESOPHAGUS	TMEM139 →	+2.769	+0.324	.003	.003	3	2
LUNG_NSCLC_LUAD	MAP3K1 →	+0.622	+0.302	.009	.003	2	3
OESOPHAGUS	RNF7 →	-0.706	-0.300	.003	.009	3	2
SKIN	PANX1 →	+0.761	+0.289	.008	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001245 vs H2BC5 — OESOPHAGUS

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