Positive regulation of intrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM51-AS1, CALR4P, and CLEC1A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of intrinsic apoptotic signaling pathway activity versus TMEM51-AS1 in COAD (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TMEM51-AS1 →	+0.291	+0.113	.003	.003	3	4
LSCC	CALR4P →	+0.145	+0.107	.007	.001	3	4
OV	CLEC1A →	+0.420	+0.151	.001	.003	3	4
CCRCC	CLMN →	+0.589	+0.120	.001	.001	3	4
CCRCC	APH1B →	+0.353	+0.145	.001	.001	3	4
UCEC	UQCC1 →	-0.314	-0.112	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001244 vs TMEM51-AS1 — COAD

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