Positive regulation of intrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of intrinsic apoptotic signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACIN1_T902, EIF2S2_S105, and HAAO, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of intrinsic apoptotic signaling pathway activity versus ACIN1_T902 in HNSC (Pearson r = -0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ACIN1_T902 →	-0.893	-0.104	<.001	.001	3	3
HNSC	EIF2S2_S105 →	-0.498	-0.088	<.001	.001	3	3
OV	HAAO →	+0.479	+0.162	<.001	<.001	3	3
OV	OSTF1 →	+0.401	+0.148	<.001	.001	3	3
BRCA	TLK2_S111 →	-0.769	-0.205	<.001	<.001	3	3
UCEC	VAPA_S164 →	-0.415	-0.147	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001244 vs ACIN1_T902 — HNSC

Explore this scatter interactively →