Regulation of intrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PMFBP1, CP, and LUC7L3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PMFBP1 grouped by Regulation of intrinsic apoptotic signaling pathway-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PMFBP1 →	+0.778	+0.117	<.001	.003	3	4
BLOOD_Leukemia	CP →	+0.242	+0.119	.008	.008	3	4
LUNG_NSCLC_LUSC	LUC7L3 →	+1.208	+0.186	.006	.009	3	4
CNS	EBAG9 →	+0.528	+0.112	.001	.004	2	5
LUNG_NSCLC_LUAD	IL17RB →	+1.117	+0.100	.001	<.001	3	4
LUNG_NSCLC_LUSC	UPP1 →	-1.966	-0.139	.006	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PMFBP1 by Regulation of intrinsic apoptotic signaling pathway activity — BLOOD_Leukemia

Explore this box plot interactively →