Regulation of intrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNTROB, PPP1R13L, and ARHGEF40, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of intrinsic apoptotic signaling pathway activity versus CNTROB in BREAST (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CNTROB →	+0.895	+0.128	.002	.001	3	6
SKIN	PPP1R13L →	-1.594	-0.167	.009	.005	3	5
BREAST	ARHGEF40 →	+1.745	+0.162	<.001	<.001	3	5
LIVER	CTAGE4 →	-2.132	-0.240	<.001	.001	3	5
URINARY_TRACT	PLRG1 →	+0.721	+0.212	.002	.001	3	5
BLOOD_Leukemia	PYGL →	+2.587	+0.179	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001242 vs CNTROB — BREAST

Explore this scatter interactively →