Regulation of chloride transport

Across TCGA patient cohorts, RNA activity of the Regulation of chloride transport pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CES2, TBC1D9B_S442, and TOP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of chloride transport activity versus CES2 in COAD (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CES2 →	+0.551	+0.070	.004	.003	3	6
OV	TBC1D9B_S442 →	+0.934	+0.079	.003	.003	3	6
LUAD	TOP1 →	-0.301	-0.075	<.001	<.001	3	6
GBM	TNKS1BP1 →	+0.310	+0.103	.001	<.001	3	6
HNSC	VRK3_S136 →	-0.508	-0.118	.005	.001	3	5
GBM	COBLL1_S814 →	+0.543	+0.094	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001225 vs CES2 — COAD

Explore this scatter interactively →