Positive regulation of neuron migration

Across TCGA cell cohorts, RNA activity of the Positive regulation of neuron migration pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF2, LAMP1, and ARL9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGEF2 grouped by Positive regulation of neuron migration-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ARHGEF2 →	-0.169	-0.571	.001	.001	3	5
CNS	LAMP1 →	-0.226	-0.891	.001	.001	3	4
CNS	ARL9 →	+0.167	+0.675	.003	.002	3	4
LUNG_NSCLC_LUAD	DRD1 →	-0.123	-0.425	<.001	.004	3	4
SKIN	PIGZ →	-0.199	-0.280	<.001	.002	3	4
BLOOD_Lymphoma	SNAP29 →	-0.202	-0.333	.005	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGEF2 by Positive regulation of neuron migration activity — CNS

Explore this box plot interactively →