Negative regulation of neuron migration

Across TCGA patient cohorts, RNA activity of the Negative regulation of neuron migration pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SGSM3, HDAC2_S422, and WFS1_S235, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of neuron migration activity versus SGSM3 in HNSC (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SGSM3 →	-0.391	-0.077	<.001	<.001	3	5
BRCA	HDAC2_S422 →	+0.496	+0.048	.008	.002	3	5
LSCC	WFS1_S235 →	-0.585	-0.062	.004	.001	3	5
COAD	TNS1_S1269 →	-0.607	-0.040	<.001	.001	3	4
PDAC	TYMP →	+0.263	+0.042	.004	.005	3	4
CCRCC	IDO1 →	+0.709	+0.055	.004	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001223 vs SGSM3 — HNSC

Explore this scatter interactively →