Negative regulation of neuron migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of neuron migration pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAK, SLC14A2, and SSX6P, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GAK grouped by Negative regulation of neuron migration-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GAK →	-0.330	-0.187	.008	.005	3	5
UPPER_AERODIGESTIVE_TRACT	SLC14A2 →	+0.141	+0.116	<.001	.007	3	4
OVARY	SSX6P →	+0.208	+0.339	.002	<.001	3	4
BREAST	CSDC2 →	-0.140	-0.244	<.001	<.001	3	4
CNS	ABL1 →	-0.158	-0.202	.002	.001	3	3
BLOOD_Myeloma	FASTK →	+0.330	+0.195	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GAK by Negative regulation of neuron migration activity — SKIN

Explore this box plot interactively →