Negative regulation of neuron migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of neuron migration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCC, CYP2R1, and ADRB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of neuron migration activity versus MCC in LUNG_SCLC (Pearson r = -0.90).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MCC →	-3.706	-2.220	.006	.001	3	3
LUNG_SCLC	CYP2R1 →	+2.790	+2.147	<.001	.001	3	3
LUNG_SCLC	ADRB1 →	-1.468	-2.242	<.001	.002	3	3
SKIN	RHEB →	-0.925	-2.159	.006	.001	3	2
SKIN	DEGS1 →	-1.264	-2.159	.005	.001	3	2
LARGE_INTESTINE	STS →	-2.506	-2.347	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001223 vs MCC — LUNG_SCLC

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