Regulation of neuron migration

Across TCGA cell cohorts, RNA activity of the Regulation of neuron migration pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFB10, MRPS14, and DLAT, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neuron migration activity versus NDUFB10 in SKIN (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NDUFB10 →	-0.558	-0.311	.001	.001	3	7
SKIN	MRPS14 →	-0.502	-0.309	.003	.005	3	7
OESOPHAGUS	DLAT →	-0.581	-0.230	.003	.007	3	6
LUNG_NSCLC_LUSC	RSL1D1 →	-0.704	-0.364	.001	.001	3	5
LUNG_NSCLC_LUAD	MTERF2 →	-0.712	-0.188	.001	<.001	3	5
BLOOD_Myeloma	DNPH1 →	-1.104	-0.254	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001222 vs NDUFB10 — SKIN

Explore this scatter interactively →