Negative regulation of osteoclast development

Across TCGA cell cohorts, RNA activity of the Negative regulation of osteoclast development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXW7, FBN1, and SEC31A, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of osteoclast development activity versus FBXW7 in LUNG_NSCLC_LUSC (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FBXW7 →	+1.085	+1.254	.008	<.001	3	16
BONE	FBN1 →	+4.414	+0.954	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	SEC31A →	+0.857	+0.955	<.001	.001	3	8
LUNG_NSCLC_LUSC	ROCK1 →	+1.125	+1.040	<.001	.002	3	8
LUNG_NSCLC_LUSC	CTSO →	+1.829	+1.381	<.001	.001	3	8
BONE	ATL3 →	+1.996	+1.264	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001205 vs FBXW7 — LUNG_NSCLC_LUSC

Explore this scatter interactively →