Negative regulation of dendritic cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of dendritic cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM176B, TMEM176A, and HLA-B, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of dendritic cell differentiation activity versus TMEM176B in LAML (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	TMEM176B →	+2.825	+0.152	<.001	<.001	3	31
CHOL	TMEM176A →	+2.771	+0.102	.002	.001	2	31
SKCM	HLA-B →	+1.595	+0.062	<.001	<.001	3	25
LAML	SLC15A3 →	+1.681	+0.097	<.001	<.001	3	25
LAML	CCR2 →	+1.951	+0.090	<.001	<.001	3	25
SARC	C2 →	+1.681	+0.064	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001199 vs TMEM176B — LAML

Explore this scatter interactively →