Regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

pathway activity — cross-omics
GO:2001188Cross-omicsPROTEIN-MS → SHRNACellPairwise association · TCGA cohorts

Across TCGA cell cohorts, RNA activity of the Regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOPBP1, PAQR8, and RCE1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TOPBP1 grouped by Regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUNG_NSCLC_LUADTOPBP1 →+0.470+0.162<.001.00531
LARGE_INTESTINEPAQR8 →-0.232-0.259.004.00131
LARGE_INTESTINERCE1 →+0.172+0.259.005.00131
LARGE_INTESTINERBM44 →+0.189+0.301.009.00131
LARGE_INTESTINEGPR88 →-0.268-0.259.009.00131
LARGE_INTESTINERNF41 →+0.246+0.259.006.00131
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TOPBP1 by Regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell activity — LUNG_NSCLC_LUAD

Box plot of TOPBP1 in Regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell-low vs -high samples in LUNG_NSCLC_LUAD.

Explore this box plot interactively →

Exploration