"Regulation of CD8-positive, alpha-beta T cell activation"

Across TCGA patient cohorts, RNA activity of the "Regulation of CD8-positive, alpha-beta T cell activation" pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCL5, KLHL11, and GOLGA5P1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of CD8-positive, alpha-beta T cell activation" activity versus CCL5 in GBM (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CCL5 →	+1.264	+0.832	<.001	<.001	3	8
LSCC	KLHL11 →	-0.389	-0.485	.001	.001	3	7
LSCC	GOLGA5P1 →	+0.873	+0.870	<.001	<.001	3	7
HNSC	TRG-AS1 →	+0.750	+0.906	<.001	<.001	3	7
LSCC	NKG7 →	+1.117	+0.940	<.001	<.001	3	7
HNSC	IFNG →	+1.247	+0.795	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001185 vs CCL5 — GBM

Explore this scatter interactively →