Positive regulation of endocytic recycling

Across TCGA patient cohorts, RNA activity of the Positive regulation of endocytic recycling pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHE, LDB2, and USHBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endocytic recycling activity versus SHE in LSCC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SHE →	+0.527	+0.431	<.001	.001	3	5
BRCA	LDB2 →	+0.643	+0.219	.001	<.001	3	5
CCRCC	USHBP1 →	+0.467	+0.146	.003	<.001	3	5
BRCA	HSPA12B →	+0.707	+0.196	.001	.001	3	5
CCRCC	EGFL7 →	+0.561	+0.142	.004	.001	3	5
CCRCC	CLEC14A →	+0.781	+0.180	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001137 vs SHE — LSCC

Explore this scatter interactively →