Positive regulation of double-strand break repair via nonhomologous end joining

Across TCGA cell cohorts, RNA activity of the Positive regulation of double-strand break repair via nonhomologous end joining pathway is significantly associated with the protein abundance of multiple proteins, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2B, HARS1, and NUP107, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of double-strand break repair via nonhomologous end joining activity versus TOP2B in STOMACH (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TOP2B →	+1.345	+0.311	.001	<.001	3	15
OVARY	HARS1 →	-1.430	-0.218	.005	.003	3	12
UPPER_AERODIGESTIVE_TRACT	NUP107 →	+0.616	+0.233	<.001	<.001	3	12
BLOOD_Myeloma	TRA2B →	+0.847	+0.284	<.001	<.001	3	12
STOMACH	NUP205 →	+0.918	+0.364	<.001	<.001	2	13
OVARY	DKC1 →	+0.924	+0.245	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001034 vs TOP2B — STOMACH

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