Regulation of double-strand break repair via nonhomologous end joining

Across TCGA patient cohorts, RNA activity of the Regulation of double-strand break repair via nonhomologous end joining pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCC2, MSH6, and SFPQ, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of double-strand break repair via nonhomologous end joining activity versus RCC2 in UCEC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RCC2 →	+0.392	+0.076	<.001	<.001	3	7
LUAD	MSH6 →	+0.403	+0.035	<.001	<.001	3	7
GBM	SFPQ →	+0.228	+0.029	.005	.007	3	6
HNSC	SMC3 →	+0.208	+0.048	.004	.006	3	6
HNSC	TMPO →	+0.261	+0.051	.005	.001	2	7
HNSC	CMTR1 →	+0.240	+0.041	.002	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001032 vs RCC2 — UCEC

Explore this scatter interactively →