Regulation of response to drug

Across TCGA patient cohorts, RNA activity of the Regulation of response to drug pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, USP54_S1531, and KLHDC7A_S365, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to drug activity versus SMC2 in COAD (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SMC2 →	-0.236	-0.036	.003	.005	2	5
OV	USP54_S1531 →	+0.593	+0.067	<.001	<.001	3	4
BRCA	KLHDC7A_S365 →	+0.845	+0.070	.003	.003	3	4
OV	DCTN3 →	+0.233	+0.057	.001	.002	3	4
CCRCC	TTC28_S2224 →	+0.274	+0.100	.005	.004	3	3
BRCA	DOT1L_S1246 →	-0.745	-0.097	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001023 vs SMC2 — COAD

Explore this scatter interactively →