Positive regulation of skeletal muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of skeletal muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOX3, GPR176, and UPP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TOX3 grouped by Positive regulation of skeletal muscle cell differentiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TOX3 →	-1.865	-0.916	.002	.002	3	6
LUNG_NSCLC_LUAD	GPR176 →	+1.882	+0.259	<.001	<.001	3	4
LUNG_NSCLC_LUSC	UPP1 →	+2.869	+0.315	.003	.009	3	4
BREAST	C19orf12 →	+0.825	+0.736	.004	<.001	3	4
SKIN	CCDC184 →	-0.420	-0.133	.005	.007	3	4
BREAST	POLH →	+0.905	+0.815	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TOX3 by Positive regulation of skeletal muscle cell differentiation activity — BREAST

Explore this box plot interactively →