Negative regulation of skeletal muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of skeletal muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMTOR3, LZTS2, and ATP6AP1L, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LAMTOR3 grouped by Negative regulation of skeletal muscle cell differentiation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LAMTOR3 →	+0.447	+0.841	.009	.007	3	3
OESOPHAGUS	LZTS2 →	-1.621	-1.433	<.001	<.001	3	3
OESOPHAGUS	ATP6AP1L →	-0.845	-0.961	.002	.001	3	3
STOMACH	PLAC8 →	+5.014	+1.604	<.001	<.001	3	3
STOMACH	FAM50B →	+2.610	+1.395	.009	.001	3	3
STOMACH	ZSCAN5B →	-0.043	-1.416	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LAMTOR3 by Negative regulation of skeletal muscle cell differentiation activity — LARGE_INTESTINE

Explore this box plot interactively →