Regulation of skeletal muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of skeletal muscle cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCOR1, SH3KBP1, and PRRC2C_T2675, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of skeletal muscle cell differentiation activity versus RCOR1 in LSCC (Pearson r = -0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RCOR1 →	+0.358	+0.067	<.001	<.001	3	6
LSCC	SH3KBP1 →	-0.400	-0.055	<.001	<.001	3	6
LSCC	PRRC2C_T2675 →	+0.566	+0.060	<.001	<.001	3	6
CCRCC	SYNPO2_T755 →	-0.811	-0.063	<.001	.001	3	5
LUAD	TNIP2 →	-0.180	-0.056	<.001	.005	2	6
PDAC	WDHD1_S383 →	+0.616	+0.065	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001014 vs RCOR1 — LSCC

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