Regulation of forebrain neuron differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of forebrain neuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are S100A4, CHD4, and STAT5A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of forebrain neuron differentiation activity versus S100A4 in GBM (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	S100A4 →	-0.829	-0.121	<.001	<.001	3	5
HNSC	CHD4 →	+0.186	+0.103	<.001	<.001	3	5
HNSC	STAT5A →	-0.339	-0.096	.006	.001	3	5
GBM	TNFAIP8L2 →	-0.500	-0.100	.002	<.001	3	5
GBM	WAS →	-0.526	-0.096	<.001	<.001	3	5
GBM	WIPF1 →	-0.198	-0.079	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000977 vs S100A4 — GBM

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