Regulation of pro-B cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of pro-B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL23AP75, UBBP1, and RPL13AP20, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of pro-B cell differentiation activity versus RPL23AP75 in CCRCC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RPL23AP75 →	+0.382	+0.562	<.001	.003	3	4
BRCA	UBBP1 →	+1.064	+0.922	<.001	.001	3	4
BRCA	RPL13AP20 →	+1.844	+1.108	<.001	<.001	3	4
BRCA	EEF1A1P7 →	+1.397	+0.978	<.001	<.001	3	4
BRCA	HNRNPA1P4 →	+1.506	+0.803	<.001	.006	2	4
BRCA	SEC11B →	+0.921	+0.991	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000973 vs RPL23AP75 — CCRCC

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