Regulation of glucocorticoid secretion

Across TCGA patient cohorts, RNA activity of the Regulation of glucocorticoid secretion pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRRX2, SATB1-AS1, and NKX2-3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glucocorticoid secretion activity versus PRRX2 in LUAD (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PRRX2 →	-1.047	-0.446	<.001	<.001	3	3
BRCA	SATB1-AS1 →	-0.219	-0.535	.004	<.001	3	3
PDAC	NKX2-3 →	+0.447	+0.307	<.001	.002	3	2
PDAC	PRPH →	+0.130	+0.301	.009	.002	3	2
COAD	ABCA8 →	+0.522	+0.368	.001	.002	3	2
COAD	XRCC2 →	-0.579	-0.484	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000849 vs PRRX2 — LUAD

Explore this scatter interactively →