Regulation of glucocorticoid secretion

Across TCGA cell cohorts, RNA activity of the Regulation of glucocorticoid secretion pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF625, RPS15, and RB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF625 grouped by Regulation of glucocorticoid secretion-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ZNF625 →	-0.665	-0.893	.003	.002	3	5
UPPER_AERODIGESTIVE_TRACT	RPS15 →	-1.056	-1.514	.001	.001	3	3
OVARY	RB1 →	-1.953	-1.512	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	TMEM190 →	+0.659	+1.344	<.001	.008	3	3
LUNG_NSCLC_LUAD	ZNF589 →	-0.641	-0.894	<.001	<.001	3	3
LUNG_NSCLC_LUSC	SEC23A →	-1.158	-1.034	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF625 by Regulation of glucocorticoid secretion activity — OVARY

Explore this box plot interactively →