Regulation of corticosteroid hormone secretion

Across TCGA patient cohorts, RNA activity of the Regulation of corticosteroid hormone secretion pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DAB2, CNRIP1, and OLFML1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of corticosteroid hormone secretion activity versus DAB2 in GBM (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DAB2 →	+0.902	+0.768	<.001	<.001	3	9
OV	CNRIP1 →	+0.677	+0.425	.001	.005	3	8
OV	OLFML1 →	+1.098	+0.448	<.001	.002	3	8
OV	PRKG1 →	+0.642	+0.304	<.001	.003	3	8
LSCC	ABCA6 →	+0.785	+0.589	<.001	.002	3	7
COAD	JAM2 →	+0.586	+0.478	<.001	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000846 vs DAB2 — GBM

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