Positive regulation of steroid hormone secretion

Across TCGA cell cohorts, RNA activity of the Positive regulation of steroid hormone secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPP1, ACCS, and GIMAP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPP1 grouped by Positive regulation of steroid hormone secretion-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SPP1 →	-0.280	-0.930	.003	.009	2	9
BLOOD_Leukemia	ACCS →	-0.202	-1.043	.002	<.001	3	4
BLOOD_Leukemia	GIMAP1 →	-0.168	-0.827	<.001	.003	3	4
KIDNEY	GNA14 →	+0.227	+1.154	<.001	.006	3	4
LUNG_NSCLC_LUAD	C1QTNF1 →	-0.129	-0.520	.003	.004	2	5
LARGE_INTESTINE	PPM1A →	+0.173	+1.023	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPP1 by Positive regulation of steroid hormone secretion activity — LUNG_NSCLC_LUSC

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