Regulation of steroid hormone secretion

Across TCGA patient cohorts, RNA activity of the Regulation of steroid hormone secretion pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRBP1, UTP6, and TNS2_S120, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of steroid hormone secretion activity versus RRBP1 in PDAC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RRBP1 →	+0.132	+0.036	.008	.006	3	5
UCEC	UTP6 →	-0.224	-0.084	.001	<.001	3	5
CCRCC	TNS2_S120 →	+0.405	+0.055	<.001	.002	3	5
CCRCC	XRN1 →	-0.173	-0.067	<.001	<.001	3	5
UCEC	PRKAR2A →	+0.143	+0.057	<.001	<.001	3	5
BRCA	SMARCC2_T322 →	-0.578	-0.031	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000831 vs RRBP1 — PDAC

Explore this scatter interactively →