Regulation of steroid hormone secretion

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of steroid hormone secretion pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 22 member genes.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher Regulation of steroid hormone secretion pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as OV and KIRC, show the opposite pattern, with higher activity associated with better survival.

BLCA, UCS, and OV are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	II,III,IV	0.644	0.785	.001	104	view →
UCS	DFS	Median	IV	0.367	0.952	.001	58	view →
OV	DFS	Tertile	II,III,IV	0.436	0.328	.005	48	view →
KIRC	OS	Median	All	0.857	0.758	<.001	38	view →
LUSC	OS	Tertile	All	0.685	0.921	<.001	30	view →
GBM	OS	Median	All	0.525	0.337	<.001	27	view →
READ	OS	Tertile	III,IV	1.000	0.388	.003	23	view →
BRCA	DFS	Quartile	III,IV	0.365	0.662	.007	18	view →
ACC	DFS	Quartile	II,III,IV	0.322	0.790	.004	16	view →
SKCM	DFS	Median	IV	0.187	0.763	.006	15	view →
SCLC	OS	Median	All	0.207	0.486	.014	13	view →
COAD	DFS	Quartile	II,III,IV	0.357	0.643	.021	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:2000831–BLCA (OS)

Open the BLCA breakdown →