Regulation of steroid hormone secretion

Across TCGA cell cohorts, RNA activity of the Regulation of steroid hormone secretion pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTF2F2, ACTR3B, and RPH3AL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GTF2F2 grouped by Regulation of steroid hormone secretion-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GTF2F2 →	-0.820	-1.459	<.001	<.001	3	4
OVARY	ACTR3B →	+1.156	+1.127	.001	.004	3	4
BLOOD_Leukemia	RPH3AL →	-1.256	-1.337	.003	<.001	3	4
BLOOD_Myeloma	ANKS3 →	+1.123	+1.426	.001	<.001	3	3
URINARY_TRACT	PFDN5 →	-0.516	-1.603	.002	<.001	3	3
LIVER	FYCO1 →	-0.720	-1.105	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GTF2F2 by Regulation of steroid hormone secretion activity — PANCREAS

Explore this box plot interactively →